I was put on the simplest diuretic BP tablet when I was in my mid-forties. It did the job for some years but then my BP was creeping up so I was put on Perindopril, an ACE inhibitor. I have been on Perindopril and Amlodipine for some time now and it is a combination that seems to work for me. I was warned that side effects of Amlodipine could include swollen ankles, but I have not had any. It is all a matter of trial and error.