Vince - do you even understand what I wrote? These are things that can be looked up in any Biochemistry textbook. Cell surface receptor theory was proven in the 60s..... If we were wrong then hormone blockers wouldn't work. Nor would insulin for diabetes, nor would half the cancer treatments in use, nor would any drug that binds to a receptor which is almost every drug in use. I literally described the Chemistry behind puberty and how it doesn't necessarily always work in the same way every time. The most thoroughly researched mutations are probably CYP-19, ER-beta and AR. There's a peer reviewed article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402034/ Which the average person should be able to understand. This research has been repeated many times since, I've just managed to find multiple repeats on PubMed - I'm assuming that if you're debating a scientific topic you know what PubMed is and why the repeats are important. If you have any evidence to disprove what we currently teach students regarding the biochemical basis of puberty which is peer-reviewed or is considered so basic that it's in a scientific textbook please share it.